Publications

Andreatta G, Kyriacou CP, Flatt T, and Costa R (2018) Aminergic Signaling Controls Ovarian Dormancy in Drosophila. Sci Rep 8:2030-018-20407-z.

Anduaga AM, Nagy D, Costa R, and Kyriacou CP (2018) Diapause in Drosophila melanogaster – Photoperiodicity, cold tolerance and metabolites. J Insect Physiol 105:46-53.

Barbera M, Escriva L, Collantes-Alegre JM, Meca G, Rosato E, and Martinez-Torres D (2018) Melatonin in the seasonal response of the aphid Acyrthosiphon pisum. Insect Sci.

Nagy D, Andreatta G, Bastianello S, Martin Anduaga A, Mazzotta G, Kyriacou CP, and Costa R (2018) A Semi-natural Approach for Studying Seasonal Diapause in Drosophila melanogaster Reveals Robust Photoperiodicity. J Biol Rhythms 33:117-125.

Noreen S, Pegoraro M, Nouroz F, Tauber E, and Kyriacou CP (2018) Interspecific studies of circadian genes period and timeless in Drosophila. Gene 648:106-114.

Zonato V, Vanin S, Costa R, Tauber E, and Kyriacou CP (2018) Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim. J Biol Rhythms 33:15-23.

Bostock E, Green EW, Kyriacou CP, and Vanin S (2017) Chronobiological studies on body search, oviposition and emergence of Megaselia scalaris (Diptera, Phoridae) in controlled conditions. Forensic Sci Int 275:155-159.

Bulla M, Oudman T, Bijleveld AI, Piersma T, and Kyriacou CP (2017) Marine biorhythms: bridging chronobiology and ecology. Philos Trans R Soc Lond B Biol Sci 372:10.1098/rstb.2016.0253.

Damulewicz M, Mazzotta GM, Sartori E, Rosato E, Costa R, and Pyza EM (2017) Cryptochrome Is a Regulator of Synaptic Plasticity in the Visual System of Drosophila melanogaster. Front Mol Neurosci 10:165.

Hunt BJ, Ozkaya O, Davies NJ, Gaten E, Seear P, Kyriacou CP, Tarling G, and Rosato E (2017a) The Euphausia superba transcriptome database, SuperbaSE: An online, open resource for researchers. Ecol Evol 7:6060-6077.

Kyriacou CP (2017) Evolution: Fruit Fly Clocks on the Edge. Curr Biol 27:R227-R230.

Kyriacou CP, Green EW, Piffer A, and Dowse HB (2017) Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detection and low-intensity courtship. Proc Natl Acad Sci U S A 114:1970-1975.

Pegoraro M, Zonato V, Tyler ER, Fedele G, Kyriacou CP, and Tauber E (2017) Geographical analysis of diapause inducibility in European Drosophila melanogaster populations. J Insect Physiol 98:238-244.

Rosato E and Kyriacou CP (2017) Staring at the Clock Face in Drosophila. Neuron 94:1046-1048.

Zonato V, Collins L, Pegoraro M, Tauber E, and Kyriacou CP (2017) Is diapause an ancient adaptation in Drosophila? J Insect Physiol 98:267-274.

Breda C, Sathyasaikumar KV, Sograte Idrissi S, Notarangelo FM, Estranero JG, Moore GG, Green EW, Kyriacou CP, Schwarcz R, and Giorgini F (2016) Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites. Proc Natl Acad Sci U S A 113:5435-5440.

Schiesari L, Andreatta G, Kyriacou CP, O’Connor MB, and Costa R (2016) The Insulin-Like Proteins dILPs-2/5 Determine Diapause Inducibility in Drosophila. PLoS One 11:e0163680.

Zonato V, Fedele G, and Kyriacou CP (2016) An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility. PLoS One 11:e0162370.

Adewoye AB, Kyriacou CP, and Tauber E (2015) Identification and functional analysis of early gene expression induced by circadian light-resetting in Drosophila. BMC Genomics 16:570-015-1787-7.

Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, and Giorgini F (2015) Rab11 modulates alpha-synuclein-mediated defects in synaptic transmission and behaviour. Hum Mol Genet 24:1077-1091.

Green EW, O’Callaghan EK, Hansen CN, Bastianello S, Bhutani S, Vanin S, Armstrong JD, Costa R, and Kyriacou CP (2015a) Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels. Proc Natl Acad Sci U S A 112:8702-8707.

Green EW, O’Callaghan EK, Pegoraro M, Armstrong JD, Costa R, and Kyriacou CP (2015b) Genetic analysis of Drosophila circadian behavior in seminatural conditions. Methods Enzymol 551:121-133.

Joseph D, Chong NW, Shanks ME, Rosato E, Taub NA, Petersen SA, Symonds ME, Whitehouse WP, and Wailoo M (2015) Getting rhythm: how do babies do it? Arch Dis Child Fetal Neonatal Ed 100:F50-4.

Montelli S, Mazzotta G, Vanin S, Caccin L, Corra S, De Pitta C, Boothroyd C, Green EW, Kyriacou CP, and Costa R (2015) period and timeless mRNA Splicing Profiles under Natural Conditions in Drosophila melanogaster. J Biol Rhythms 30:217-227.

O’Neill JS, Lee KD, Zhang L, Feeney K, Webster SG, Blades MJ, Kyriacou CP, Hastings MH, and Wilcockson DC (2015) Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra. Curr Biol 25:R326-7.

Pegoraro M, Picot E, Hansen CN, Kyriacou CP, Rosato E, and Tauber E (2015a) Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Front Neurol 6:100.

Pegoraro M, Picot E, Hansen CN, Kyriacou CP, Rosato E, and Tauber E (2015b) Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Front Neurol 6:100.

Rosato E, Gigante A, Liberatori M, Gasperini ML, Sardo L, Amoroso A, and Tubani L (2015) QTc interval prolongation in systemic sclerosis: correlations with clinical variables. Int J Cardiol 182:20-22.

Dissel S, Hansen CN, Ozkaya O, Hemsley M, Kyriacou CP, and Rosato E (2014a) The logic of circadian organization in Drosophila. Curr Biol 24:2257-2266.

Dissel S, Hansen CN, Ozkaya O, Hemsley M, Kyriacou CP, and Rosato E (2014b) The logic of circadian organization in Drosophila. Curr Biol 24:2257-2266.

Fedele G, Edwards MD, Bhutani S, Hares JM, Murbach M, Green EW, Dissel S, Hastings MH, Rosato E, and Kyriacou CP (2014a) Genetic analysis of circadian responses to low frequency electromagnetic fields in Drosophila melanogaster. PLoS Genet 10:e1004804.

Fedele G, Green EW, Rosato E, and Kyriacou CP (2014c) An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway. Nat Commun 5:4391.

Green EW, Fedele G, Giorgini F, and Kyriacou CP (2014) A Drosophila RNAi collection is subject to dominant phenotypic effects. Nat Methods 11:222-223.

Kijak E, Rosato E, Knapczyk K, and Pyza E (2014) Drosophila melanogaster as a model system of aluminum toxicity and aging. Insect Sci 21:189-202.

Kyriacou CP (2014a) Sex and rhythms in sandflies and mosquitoes: an appreciation of the work of Alexandre Afranio Peixoto (1963-2013). Infect Genet Evol 28:662-665.

Kyriacou CP (2014b) Alexandre Afranio Peixoto (1963-2013). Infect Genet Evol 28:757-758.

Pegoraro M, Gesto JS, Kyriacou CP, and Tauber E (2014a) Role for circadian clock genes in seasonal timing: testing the Bunning hypothesis. PLoS Genet 10:e1004603.

Pegoraro M, Noreen S, Bhutani S, Tsolou A, Schmid R, Kyriacou CP, and Tauber E (2014b) Molecular evolution of a pervasive natural amino-acid substitution in Drosophila cryptochrome. PLoS One 9:e86483.

Seear PJ, Head ML, Tilley CA, Rosato E, and Barber I (2014) Flow-mediated plasticity in the expression of stickleback nesting glue genes. Ecol Evol 4:1233-1242.

Allebrandt KV, Amin N, Muller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, and Roenneberg T (2013) A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry 18:122-132.

Bartok O, Kyriacou CP, Levine J, Sehgal A, and Kadener S (2013) Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. Proc Biol Sci 280:20130011.

Damulewicz M, Rosato E, and Pyza E (2013) Circadian regulation of the Na+/K+-ATPase alpha subunit in the visual system is mediated by the pacemaker and by retina photoreceptors in Drosophila melanogaster. PLoS One 8:e73690.

Hut RA, Paolucci S, Dor R, Kyriacou CP, and Daan S (2013) Latitudinal clines: an evolutionary view on biological rhythms. Proc Biol Sci 280:20130433.

Kyriacou CP (2013) Animal behaviour: monarchs catch a cold. Curr Biol 23:R235-6.

Mason RP, Casu M, Butler N, Breda C, Campesan S, Clapp J, Green EW, Dhulkhed D, Kyriacou CP, and Giorgini F (2013) Glutathione peroxidase activity is neuroprotective in models of Huntington’s disease. Nat Genet 45:1249-1254.

Meireles-Filho AC and Kyriacou CP (2013) Circadian rhythms in insect disease vectors. Mem Inst Oswaldo Cruz 108 Suppl 1:48-58.

Menegazzi P, Vanin S, Yoshii T, Rieger D, Hermann C, Dusik V, Kyriacou CP, Helfrich-Forster C, and Costa R (2013) Drosophila clock neurons under natural conditions. J Biol Rhythms 28:3-14.

Zhang L, Hastings MH, Green EW, Tauber E, Sladek M, Webster SG, Kyriacou CP, and Wilcockson DC (2013) Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. Curr Biol 23:1863-1873.

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, and Reddy AB (2012) Peroxiredoxins are conserved markers of circadian rhythms. Nature 485:459-464.

Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, and Giorgini F (2012) Drosophila eye color mutants as therapeutic tools for Huntington disease. Fly (Austin) 6:117-120.

Ozkaya O and Rosato E (2012) The circadian clock of the fly: a neurogenetics journey through time. Adv Genet 77:79-123.

Steinert JR, Campesan S, Richards P, Kyriacou CP, Forsythe ID, and Giorgini F (2012) Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington’s disease. Hum Mol Genet 21:2912-2922.

Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, and Kyriacou CP (2012) Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature 484:371-375.

Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, and Giorgini F (2011) The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington’s disease. Curr Biol 21:961-966.

Rosato E and Kyriacou CP (2011) The role of natural selection in circadian behaviour: a molecular-genetic approach. Essays Biochem 49:71-85.

Schiesari L, Kyriacou CP, and Costa R (2011) The hormonal and circadian basis for insect photoperiodic timing. FEBS Lett 585:1450-1460.

Wilcockson DC, Zhang L, Hastings MH, Kyriacou CP, and Webster SG (2011) A novel form of pigment-dispersing hormone in the central nervous system of the intertidal marine isopod, Eurydice pulchra (leach). J Comp Neurol 519:562-575.

Benna C, Bonaccorsi S, Wulbeck C, Helfrich-Forster C, Gatti M, Kyriacou CP, Costa R, and Sandrelli F (2010) Drosophila timeless2 is required for chromosome stability and circadian photoreception. Curr Biol 20:346-352.

Ben-Shlomo R and Kyriacou CP (2010) Light pulses administered during the circadian dark phase alter expression of cell cycle associated transcripts in mouse brain. Cancer Genet Cytogenet 197:65-70.

Kyriacou CP and Hastings MH (2010) Circadian clocks: genes, sleep, and cognition. Trends Cogn Sci 14:259-267.

Seear PJ, Tarling GA, Burns G, Goodall-Copestake WP, Gaten E, Ozkaya O, and Rosato E (2010) Differential gene expression during the moult cycle of Antarctic krill (Euphausia superba). BMC Genomics 11:582-2164-11-582.

Alghamdi A, Raine NE, Rosato E, and Mallon EB (2009) No evidence for an evolutionary trade-off between learning and immunity in a social insect. Biol Lett 5:55-57.

Deery MJ, Maywood ES, Chesham JE, Sladek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, and Hastings MH (2009) Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. Curr Biol 19:2031-2036.

Kyriacou CP (2009a) Clocks, cryptochromes and Monarch migrations. J Biol 8:55.

Kyriacou CP (2009b) Physiology. Unraveling traveling. Science 325:1629-1630.

Last KS, Bailhache T, Kramer C, Kyriacou CP, Rosato E, and Olive PJ (2009) Tidal, daily, and lunar-day activity cycles in the marine polychaete Nereis virens. Chronobiol Int 26:167-183.

Moran CN and Kyriacou CP (2009) Functional neurogenomics of the courtship song of male Drosophila melanogaster. Cortex 45:18-34.

Alghamdi A, Dalton L, Phillis A, Rosato E, and Mallon EB (2008) Immune response impairs learning in free-flying bumble-bees. Biol Lett 4:479-481.

Gaten E, Tarling G, Dowse H, Kyriacou C, and Rosato E (2008) Is vertical migration in Antarctic krill (Euphausia superba) influenced by an underlying circadian rhythm? J Genet 87:473-483.

Kyriacou CP, Peixoto AA, Sandrelli F, Costa R, and Tauber E (2008) Clines in clock genes: fine-tuning circadian rhythms to the environment. Trends Genet 24:124-132.

Rosato E and Kyriacou CP (2008) Sleep, arousal, and rhythms in flies. Proc Natl Acad Sci U S A 105:19567-19568.

Rosato E and Salsano F (2008) Immunity, autoimmunity and autoimmune diseases in older people. J Biol Regul Homeost Agents 22:217-224.

Sandrelli F, Costa R, Kyriacou CP, and Rosato E (2008) Comparative analysis of circadian clock genes in insects. Insect Mol Biol 17:447-463.

Codd V, Dolezel D, Stehlik J, Piccin A, Garner KJ, Racey SN, Straatman KR, Louis EJ, Costa R, Sauman I, Kyriacou CP, and Rosato E (2007) Circadian rhythm gene regulation in the housefly Musca domestica. Genetics 177:1539-1551.

Hemsley MJ, Mazzotta GM, Mason M, Dissel S, Toppo S, Pagano MA, Sandrelli F, Meggio F, Rosato E, Costa R, and Tosatto SC (2007) Linear motifs in the C-terminus of D. melanogaster cryptochrome. Biochem Biophys Res Commun 355:531-537.

Kyriacou CP (2007) Behavioural genetics: sex, flies and acetate. Nature 446:502-504.

Kyriacou CP, Peixoto AA, and Costa R (2007) A cline in the Drosophila melanogaster period gene in Australia: neither down nor under. J Evol Biol 20:1649-1651.

Maywood ES, O’Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, and Hastings MH (2007) Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Harb Symp Quant Biol 72:85-94.

Mehnert KI, Beramendi A, Elghazali F, Negro P, Kyriacou CP, and Cantera R (2007) Circadian changes in Drosophila motor terminals. Dev Neurobiol 67:415-421.

Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, and Hastings MH (2007) Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology 45:1478-1488.

Sandrelli F, Cappellozza S, Benna C, Saviane A, Mastella A, Mazzotta GM, Moreau S, Pegoraro M, Piccin A, Zordan MA, Cappellozza L, Kyriacou CP, and Costa R (2007a) Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori. Genet Res 89:73-84.

Sandrelli F, Tauber E, Pegoraro M, Mazzotta G, Cisotto P, Landskron J, Stanewsky R, Piccin A, Rosato E, Zordan M, Costa R, and Kyriacou CP (2007b) A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science 316:1898-1900.

Tauber E, Zordan M, Sandrelli F, Pegoraro M, Osterwalder N, Breda C, Daga A, Selmin A, Monger K, Benna C, Rosato E, Kyriacou CP, and Costa R (2007a) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316:1895-1898.

Ashburner M and Kyriacou CP (2006) Getting a buzz out of the bee genome. Genome Biol 7:239-2006-7-10-239. Epub 2006 Oct 26.

Mazzoni CJ, Souza NA, Andrade-Coelho C, Kyriacou CP, and Peixoto AA (2006) Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani. BMC Evol Biol 6:85-2148-6-85.

Meireles-Filho AC, Amoretty PR, Souza NA, Kyriacou CP, and Peixoto AA (2006) Rhythmic expression of the cycle gene in a hematophagous insect vector. BMC Mol Biol 7:38-2199-7-38.

Reddy AB, Karp NA, Maywood ES, Sage EA, Deery M, O’Neill JS, Wong GK, Chesham J, Odell M, Lilley KS, Kyriacou CP, and Hastings MH (2006) Circadian orchestration of the hepatic proteome. Curr Biol 16:1107-1115.

Rosato E and Kyriacou CP (2006) Analysis of locomotor activity rhythms in Drosophila. Nat Protoc 1:559-568.

Rosato E, Tauber E, and Kyriacou CP (2006a) Molecular genetics of the fruit-fly circadian clock. Eur J Hum Genet 14:729-738.

Sawyer LA, Sandrelli F, Pasetto C, Peixoto AA, Rosato E, Costa R, and Kyriacou CP (2006) The period gene Thr-Gly polymorphism in Australian and African Drosophila melanogaster populations: implications for selection. Genetics 174:465-480.

Ben-Shlomo R, Akhtar RA, Collins BH, Judah DJ, Davies R, and Kyriacou CP (2005) Light pulse-induced heme and iron-associated transcripts in mouse brain: a microarray analysis. Chronobiol Int 22:455-471.

Collins BH, Dissel S, Gaten E, Rosato E, and Kyriacou CP (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc Natl Acad Sci U S A 102:19021-19026.

Kyriacou CP (2005) Behavioural genetics: sex in fruitflies is fruitless. Nature 436:334-335.

Mazzotta GM, Sandrelli F, Zordan MA, Mason M, Benna C, Cisotto P, Rosato E, Kyriacou CP, and Costa R (2005) The clock gene period in the medfly Ceratitis capitata. Genet Res 86:13-30.

Sharma P, Asztalos Z, Ayyub C, de Bruyne M, Dornan AJ, Gomez-Hernandez A, Keane J, Killeen J, Kramer S, Madhavan M, Roe H, Sherkhane PD, Siddiqi K, Silva E, Carlson JR, Goodwin SF, Heisenberg M, Krishnan K, Kyriacou CP, Partridge L, Riesgo-Escovar J, Rodrigues V, Tully T, and O’Kane CJ (2005) Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. J Neurogenet 19:57-85.

Tauber E and Kyriacou CP (2005) Molecular evolution and population genetics of circadian clock genes. Methods Enzymol 393:797-817.

Collins BH, Rosato E, and Kyriacou CP (2004) Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C. Proc Natl Acad Sci U S A 101:1945-1950.

Dissel S, Codd V, Fedic R, Garner KJ, Costa R, Kyriacou CP, and Rosato E (2004) A constitutively active cryptochrome in Drosophila melanogaster. Nat Neurosci 7:834-840.

Rogers AS, Escher SA, Pasetto C, Rosato E, Costa R, and Kyriacou CP (2004a) A mutation in Drosophila simulans that lengthens the circadian period of locomotor activity. Genetica 120:223-232.

Rogers AS, Rosato E, Costa R, and Kyriacou CP (2004b) Molecular analysis of circadian clocks in Drosophila simulans. Genetica 120:213-222.

Souza NA, Vigoder FM, Araki AS, Ward RD, Kyriacou CP, and Peixoto AA (2004) Analysis of the copulatory courtship songs of Lutzomyia longipalpis in six populations from Brazil. J Med Entomol 41:906-913.

Tauber E, Last KS, Olive PJ, and Kyriacou CP (2004) Clock gene evolution and functional divergence. J Biol Rhythms 19:445-458.

Tauber E, Roe H, Costa R, Hennessy JM, and Kyriacou CP (2003) Temporal mating isolation driven by a behavioral gene in Drosophila. Curr Biol 13:140-145.

Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH, and Kyriacou CP (2002) Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 12:540-550.

Bauzer LG, Gesto JS, Souza NA, Ward RD, Hamilton JG, Kyriacou CP, and Peixoto AA (2002a) Molecular divergence in the period gene between two putative sympatric species of the Lutzomyia longipalpis complex. Mol Biol Evol 19:1624-1627.

Bauzer LG, Souza NA, Ward RD, Kyriacou CP, and Peixoto AA (2002b) The period gene and genetic differentiation between three Brazilian populations of Lutzomyia longipalpis. Insect Mol Biol 11:315-323.

Ben-Shlomo R and Kyriacou CP (2002) Circadian rhythm entrainment in flies and mammals. Cell Biochem Biophys 37:141-156.

de Souza NA, Ward RD, Hamilton JG, Kyriacou CP, and Peixoto AA (2002) Copulation songs in three siblings of Lutzomyia longipalpis (Diptera: Psychodidae). Trans R Soc Trop Med Hyg 96:102-103.

Kyriacou CP (2002) Single gene mutations in Drosophila: what can they tell us about the evolution of sexual behaviour? Genetica 116:197-203.

Lins RM, Oliveira SG, Souza NA, de Queiroz RG, Justiniano SC, Ward RD, Kyriacou CP, and Peixoto AA (2002) Molecular evolution of the cacophony IVS6 region in sandflies. Insect Mol Biol 11:117-122.

Mazzoni CJ, Gomes CA, Souza NA, de Queiroz RG, Justiniano SC, Ward RD, Kyriacou CP, and Peixoto AA (2002) Molecular evolution of the period gene in sandflies. J Mol Evol 55:553-562.

Rosato E and Kyriacou CP (2002) Origins of circadian rhythmicity. J Biol Rhythms 17:506-511.

Vodovar N, Clayton JD, Costa R, Odell M, and Kyriacou CP (2002) The Drosophila clock protein Timeless is a member of the Arm/HEAT family. Curr Biol 12:R610-1.

Campesan S, Chalmers D, Sandrelli F, Megighian A, Peixoto AA, Costa R, and Kyriacou CP (2001a) Comparative analysis of the nonA region in Drosophila identifies a highly diverged 5′ gene that may constrain nonA promoter evolution. Genetics 157:751-764.

Campesan S, Dubrova Y, Hall JC, and Kyriacou CP (2001b) The nonA gene in Drosophila conveys species-specific behavioral characteristics. Genetics 158:1535-1543.

Clayton JD, Kyriacou CP, and Reppert SM (2001) Keeping time with the human genome. Nature 409:829-831.

Kyriacou CP and Hastings M (2001) Keystone clocks. Trends Neurosci 24:434-435.

Peixoto AA, Gomes CA, de Amoretty PR, Lins RM, Meireles-Filho AC, de Souza NA, and Kyriacou CP (2001) New molecular markers for phlebotomine sand flies. Int J Parasitol 31:635-639.

Piccin A, Salameh A, Benna C, Sandrelli F, Mazzotta G, Zordan M, Rosato E, Kyriacou CP, and Costa R (2001) Efficient and heritable functional knock-out of an adult phenotype in Drosophila using a GAL4-driven hairpin RNA incorporating a heterologous spacer. Nucleic Acids Res 29:E55-5.

Rosato E, Codd V, Mazzotta G, Piccin A, Zordan M, Costa R, and Kyriacou CP (2001) Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Curr Biol 11:909-917.

Rosato E and Kyriacou CP (2001) Flies, clocks and evolution. Philos Trans R Soc Lond B Biol Sci 356:1769-1778.

Zordan M, Osterwalder N, Rosato E, and Costa R (2001a) Extra ocular photic entrainment in Drosophila melanogaster. J Neurogenet 15:97-116.

Zordan MA, Rosato E, Piccin A, and Foster R (2001b) Photic entrainment of the circadian clock: from Drosophila to mammals. Semin Cell Dev Biol 12:317-328.

Benna C, Scannapieco P, Piccin A, Sandrelli F, Zordan M, Rosato E, Kyriacou CP, Valle G, and Costa R (2000) A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Curr Biol 10:R512-3.

Kyriacou CP and Rosato E (2000) Squaring up the E-box. J Biol Rhythms 15:483-490.

Piccin A, Couchman M, Clayton JD, Chalmers D, Costa R, and Kyriacou CP (2000) The clock gene period of the housefly, Musca domestica, rescues behavioral rhythmicity in Drosophila melanogaster. Evidence for intermolecular coevolution? Genetics 154:747-758.

Zordan M and Kyriacou CP (2000) The circadian clock in mammals. J Headache Pain 1 Suppl 2:S103-7.

Demetriades MC, Thackeray JR, and Kyriacou CP (1999) Courtship song rhythms in Drosophila yakuba. Anim Behav 57:379-386.

Guantieri V, Pepe A, Zordan M, Kyriacou CP, Costa R, and Tamburro AM (1999) Different period gene repeats take ‘turns’ at fine-tuning the circadian clock. Proc Biol Sci 266:2283-2288.

Costa R and Kyriacou CP (1998) Functional and evolutionary implications of natural variation in clock genes. Curr Opin Neurobiol 8:659-664.

Peixoto AA, Hennessy JM, Townson I, Hasan G, Rosbash M, Costa R, and Kyriacou CP (1998) Molecular coevolution within a Drosophila clock gene. Proc Natl Acad Sci U S A 95:4475-4480.

Rosato E, Peixoto AA, Costa R, and Kyriacou CP (1997a) Linkage disequilibrium, mutational analysis and natural selection in the repetitive region of the clock gene, period, in Drosophila melanogaster. Genet Res 69:89-99.

Rosato E, Piccin A, and Kyriacou CP (1997) Circadian rhythms: from behaviour to molecules. Bioessays 19:1075-1082.

Rosato E, Trevisan A, Sandrelli F, Zordan M, Kyriacou CP, and Costa R (1997d) Conceptual translation of timeless reveals alternative initiating methionines in Drosophila. Nucleic Acids Res 25:455-458.

Sawyer LA, Hennessy JM, Peixoto AA, Rosato E, Parkinson H, Costa R, and Kyriacou CP (1997a) Natural variation in a Drosophila clock gene and temperature compensation. Science 278:2117-2120.

Konopka RJ, Kyriacou CP, and Hall JC (1996) Mosaic analysis in the Drosophila CNS of circadian and courtship-song rhythms affected by a period clock mutation. J Neurogenet 11:117-139.

Rosato E, Peixoto AA, Gallippi A, Kyriacou CP, and Costa R (1996a) Mutational mechanisms, phylogeny, and evolution of a repetitive region within a clock gene of Drosophila melanogaster. J Mol Evol 42:392-408.

Castiglione-Morelli MA, Guantieri V, Villani V, Kyriacou CP, Costa R, and Tamburro AM (1995) Conformational study of the Thr-Gly repeat in the Drosophila clock protein, PERIOD. Proc Biol Sci 260:155-163.

Kyriacou CP (1994a) Clock research perring along: it’s about time! Trends Genet 10:69-71.

Kyriacou CP (1994b) Working round the clock with mouse 25. Trends Neurosci 17:313-314.

Kyriacou CP and Hall JC (1994) Genetic and molecular analysis of Drosophila behavior. Adv Genet 31:139-186.

Nielsen J, Peixoto AA, Piccin A, Costa R, Kyriacou CP, and Chalmers D (1994) Big flies, small repeats: the “Thr-Gly” region of the period gene in Diptera. Mol Biol Evol 11:839-853.

Ritchie MG and Kyriacou CP (1994) Reproductive isolation and the period gene of Drosophila. Mol Ecol 3:595-599.

Ritchie MG, Yate VH, and Kyriacou CP (1994) Genetic variability of the interpulse interval of courtship song among some European populations of Drosophila melanogaster. Heredity (Edinb) 72 ( Pt 5):459-464.

Rosato E, Peixoto AA, Barbujani G, Costa R, and Kyriacou CP (1994) Molecular polymorphism in the period gene of Drosophila simulans. Genetics 138:693-707.

Chalmers DE and Kyriacou CP (1993) Glowing reports on biorhythm research. Bioessays 15:755-756.

Greenacre ML, Ritchie MG, Byrne BC, and Kyriacou CP (1993) Female song preference and the period gene in Drosophila. Behav Genet 23:85-90.

Peixoto AA, Campesan S, Costa R, and Kyriacou CP (1993) Molecular evolution of a repetitive region within the per gene of Drosophila. Mol Biol Evol 10:127-139.

Costa R, Peixoto AA, Barbujani G, and Kyriacou CP (1992) A latitudinal cline in a Drosophila clock gene. Proc Biol Sci 250:43-49.

Kyriacou CP (1992) Sex variations. Trends Genet 8:261-263.

Peixoto AA, Costa R, Wheeler DA, Hall JC, and Kyriacou CP (1992) Evolution of the threonine-glycine repeat region of the period gene in the melanogaster species subgroup of Drosophila. J Mol Evol 35:411-419.

Costa R, Peixoto AA, Thackeray JR, Dalgleish R, and Kyriacou CP (1991) Length polymorphism in the threonine-glycine-encoding repeat region of the period gene in Drosophila. J Mol Evol 32:238-246.

Wheeler DA, Kyriacou CP, Greenacre ML, Yu Q, Rutila JE, Rosbash M, and Hall JC (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science 251:1082-1085.

Dushay MS, Konopka RJ, Orr D, Greenacre ML, Kyriacou CP, Rosbash M, and Hall JC (1990) Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. Genetics 125:557-578.

Kyriacou CP (1990) The molecular ethology of the period gene in Drosophila. Behav Genet 20:191-211.

Kyriacou CP and Hall JC (1990) Song rhythms in Drosophila. Trends Ecol Evol 5:125-126.

Kyriacou CP, Oldroyd M, Wood J, Sharp M, and Hill M (1990a) Clock mutations alter developmental timing in Drosophila. Heredity (Edinb) 64 ( Pt 3):395-401.

Kyriacou CP, van den Berg MJ, and Hall JC (1990b) Drosophila courtship song cycles in normal and period mutant males revisited. Behav Genet 20:617-644.

Thackeray JR and Kyriacou CP (1990) Molecular evolution in the Drosophila yakuba period locus. J Mol Evol 31:389-401.

Yu Q, Colot HV, Kyriacou CP, Hall JC, and Rosbash M (1987) Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila. Nature 326:765-769.

Hamblen M, Zehring WA, Kyriacou CP, Reddy P, Yu Q, Wheeler DA, Zwiebel LJ, Konopka RJ, Rosbash M, and Hall JC (1986) Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. J Neurogenet 3:249-291.

Kyriacou CP and Hall JC (1986) Interspecific genetic control of courtship song production and reception in Drosophila. Science 232:494-497.

Kyriacou CP (1985) Long-term Ebony polymorphisms: a comparison of the contributions of behavioral and nonbehavioral fitness characters. Behav Genet 15:165-180.

Kyriacou CP and Hall JC (1985) Action potential mutations stop a biological clock in Drosophila. Nature 314:171-173.

Kyriacou CP and Hall JC (1984) Learning and memory mutations impair acoustic priming of mating behaviour in Drosophila. Nature 308:62-65.

Siegel RW, Hall JC, Gailey DA, and Kyriacou CP (1984) Genetic elements of courtship in Drosophila: mosaics and learning mutants. Behav Genet 14:383-410.

Zehring WA, Wheeler DA, Reddy P, Konopka RJ, Kyriacou CP, Rosbash M, and Hall JC (1984) P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell 39:369-376.

Hall JC, Tompkins L, Kyriacou CP, Siegel RW, von Schilcher F, and Greenspan RJ (1980) Higher behavior in Drosophila analyzed with mutations that disrupt the structure and function of the nervous system. Basic Life Sci 16:425-455.

Kyriacou CP and Hall JC (1980) Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male’s courtship song. Proc Natl Acad Sci U S A 77:6729-6733.

Kyriacou CP and Burnet B (1979) Genetic analysis of phototaxis near the upper limit of the visual spectrum of Drosophila melanogaster. Behav Genet 9:123-128.